Fig. 3
From: Low-intensity open-field blast exposure effects on neurovascular unit ultrastructure in mice
Ultrastructural abnormalities of endothelial cells in mouse brains post-LIB exposure. (a) Representative electron micrographs of microvessels in sham controls and LIB-exposed mice. Endothelial cells (EC) are highlighted in blue in sham controls and pink in LIB-exposed mice at 7 DPI. Scale bar, 1 μm. (b) Red arrows indicate vacuoles within endothelial cells in LIB-exposed mice at 7 DPI. Scale bar, 1 μm. (c) Quantifications of electron micrographs reveal relative endothelial cell areas and densities of vacuoles in sham controls and LIB-exposed mice at 7 and 30 DPI. *, p < 0.05 and ****, p < 0.0001. Data are expressed as median and interquartile range. (d) Red arrows and red asterisks indicate ultrastructural abnormalities of endothelial cells (EC) in LIB-exposed mice, including density inconsistencies (d1) and abnormal bulges (d2) at 7 DPI, as well as endothelial cell detachments (d3 at 30 DPI and d4 at 7 DPI). Scale bar, 0.5 μm