Fig. 9

IFNAR deficiency reduces white matter disruption 7 days following TBI.

Difference in white matter fiber tracts between WT and IFNAR KO TBI mice using diffusion tensor imaging. T-statistical maps of the lesion epicenter showing the decrease in fractional anisotropy (FA) in WT TBI vs. WT control (A) and IFNAR KO TBI vs. IFNAR KO control (B) at 7 DPI. The f-statistic of WT TBI vs. IFNAR KO TBI (C) showing significantly larger decrease in FA in WT TBI compared to IFNAR KO TBI. Images are overlaid onto a representative TBI image with the mean FA skeleton shown in green. Areas of decreased FA are shown in blue. Distance from bregma in mm is shown along the bottom and distance from bregma shown below. n = 15–17 mice/group