Fig. 1

TBI results in rapid and sustained ISG expression in both focal and remote regions of the brain. ISG expression was assessed from ipsilateral cortex (A) or hippocampus (B) at various timepoints post injury by qPCR. Data are expressed as fold change relative to sham. Error bars depict mean ± SEM. Significance determined by two-tailed unpaired t-tests for normally distributed data and Mann-Whitney U tests for non-normally distributed data comparing sham vs. FPI for each gene at each time point. *p < 0.05 TBI compared to sham, †p < 0.10 TBI compared to sham, n = 4–5 mice/group. (C-F) Representative confocal images demonstrating TBI-induced, microglial Irf7 expression. At 7 days post-TBI, Irf7 co-localized with the microglial marker, IBA1 (Scale bar, 50 μm)