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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: Inhibition of acid sphingomyelinase reduces reactive astrocyte secretion of mitotoxic extracellular vesicles and improves Alzheimer’s disease pathology in the 5xFAD mouse

Fig. 7

Imipramine reduces mitotoxicity of 5xFAD brain-derived EVs. A Bioenergetics of neuronal cells incubated with brain derived EVs of WT, 5xFAD treated with vehicle or Imipramine assessed by Seahorse Flux Analyzer using Cell Mito Stress Kit. Lines and Box and Whiskers plot represent average ± SD with each N = 4/group. B One-way ANOVA, Dunnett’s posthoc testing (*p < 0.05, **p < 0.01, ***p < 0.001). C Extracellular acidification rate (ECAR) of neuronal cells incubated with brain-derived EVs of WT, 5xFAD mice treated with vehicle or Imipramine. Lines represent average ± SD with each N = 4/group

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Acta Neuropathologica Communications

ISSN: 2051-5960

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