Table 4 Down syndrome Alzheimer’s disease (AD-DS) and matched disomic Alzheimer’s disease (EOAD) and healthy ageing case details. Summary of case demographics information of human post-mortem cases from matched disomic healthy ageing, EOAD and AD-DS cases, including age at death, post-mortem-interval, APOE genotype and Braak Tangle Stage

Gender

4 Male, 6 Female

4 Male, 6 Female

4 Male, 6 Female

Age at death (years)

68.3 \(\pm\) 5.72

60.8 \(\pm\) 6.03

60.2 \(\pm\) 6.25

Post-mortem interval (h)

32.86 \(\pm\) 15.27

30.73 \(\pm\) 18.88

38.40 \(\pm\) 19.74

APOE genotype (number of individuals)

2/3, 2/4 (2),

3/3 (5),

3/4, 4/4 (2),

unknown (1)

2/3, 2/4 (2),

3/3 (3),

3/4, 4/4 (5)

2/3, 2/4 (2),

3/3 (5),

3/4, 4/4 (3)

Braak Tangle Stage

(Number of individuals)

Not staged (6)

0 (1),

I (1),

II (2)

V (1)

VI (9)

Not staged (1)

IV (1)

V (2)

VI (6)