Fig. 7
From: Novel histotypes of sporadic Creutzfeldt–Jakob disease linked to 129MV genotype
Western blot profiles of sCJDMV resPrPSc. Only the unglycosylated isoform of resPrPSc is shown for convenience. a 1C histotype with short disease duration harbors T120; control (ctl): T120-T2. b(i) 1C-2PL featuring T120 in the cerebral cortex, and T120 co-existing with a minor T121 fragment in subcortical regions; ctl: T121. b(ii) T2 is detected in the entorhinal corte (EC), and subcortical regions. c(i) In 1C-2K T120 is detected in all brain regions, T120-T2 in the SN; Ctl: T121. c(ii) T2 is detected in the EC, occipital cortex (OC), and subcortical regions; ctl: T2. d 2C with “pure” T2 detected in all brain regions; ctl: T120; arrowhead: lower resPrPSc fragment of ~ 18 kDa. e 2C-PL with co-existing T121 and T120 variants, and predominant of T121; ctl: T120. f 2C-K with predominant T121 in hippocampus (HI), and predominant T120 in the EC, and subcortical regions; ctl: T120; arrowhead: lower resPrPSc fragment of ~ 18 kDa. g 2K featuring T120-T2 with a prominent T2 in cerebral cortex; inset: shorter time of film exposure. FCs: frontal cortex, superior gyrus; FCM: FC, middle gyrus; TC: temporal cortex; PC: pariental cortex; VC: visual cortex; ST: striatum; anterior thalamus (TH); substantia nigra (SN) of midbrain; CE: cerebellum. d–g Percentage of cortical coarse PrP is indicated in green