Fig. 6
From: Novel histotypes of sporadic Creutzfeldt–Jakob disease linked to 129MV genotype
Ring doughnut charts depicting distributions of sCJDMV histotypes and clinical features at presentation. a Of the 31 cases from combined MV1/MV1-2 subtypes, 21 (68%) belong to the 1C histotype, and only one (3%) to the 1V histotype. 1C-2PL, 1C-2K and 1C-2C histotypes account for 10%, 13% and 6%, respectively. b Of 73 MV2-1, 2C-K (55%) and 2C (31%) are the most common histotypes; with 7% prevalence, 2C-PL and 2K are the rarest histotypes. c and d The mean age at onset is 70 years in MV1-2 and MV2-1. e The 1C histotype includes cases with short (red dots) and long (black dots) disease course. Unlike most 1C cases, disease duration is longer in 1V, 1C-2PL, 1C-2K and 1C-2C histotypes. f 2C histotype shows the longest disease duration; *P < 0.03. g–o With the exception of the 2K histotype (o), cognitive decline is the most common symptom at disease onset (g–n)