Fig. 5

Histopathology of 2C, 2C-PL, 2C-K and 2K. a–f H&E. g–n PrP immunostaining. a, b Large and confluent vacuoles. c, e Deep layers with small and large vacuoles (c), and small vacuoles (e); arrow, c large vacuoles. d, f Superficial layers with reduced vacuole density. g Coarse PrP; inset, large magnification of perivacuolar PrP. h–j Plaque-like PrP (arrows) in a background of diffuse PrP and/or PrP arrays; inset, h plaque-like PrP (arrow). k, l Coarse PrP; Mol. L: Molecular layer; Grl L: granular layer. m, n Coarse PrP deposits (m) and PrP plaques (arrowhead) (m, n); inset, m a PrP plaque; antibody: 3F4