Fig. 4
From: Novel histotypes of sporadic Creutzfeldt–Jakob disease linked to 129MV genotype
Histopathology of 1C-2K. a and b, inset in f H&E. c–f PrP immunostaining. a Small and mid-size vacuoles. b Lack of spongiform degeneration in the CA4 region of the hippocampus. c Diffuse PrP immunostaining; arrow: larger PrP granules. d Granular PrP staining. e “Brush stroke-like” (arrows) and PrP plaques (arrowheads); Mol. L.: molecular layer; Grl. L.: granular layer. f PrP plaque (arrowhead) and plaque-like (arrow) deposits; inset: a cluster of the kuru plaques; bar size: 20 µm; antibody: 3F4