Fig. 3
From: Novel histotypes of sporadic Creutzfeldt–Jakob disease linked to 129MV genotype
Histopathology of 1C, 1C-2PL and 1C-2C. row i H&E. rows ii, iii and insets in row i PrP immunostaining. a, b Spongiform degeneration (SD) and gliosis; arrows: astrocytes; insets: diffuse PrP. c SD with small and occasionally large vacuoles; inset (left): large vacuoles; inset (right): perivacuolar PrP. d and f Diffuse PrP. e Plaque-like PrP; arrow: a plaque-like PrP formation. g-i “Brush stroke-like” PrP affecting the molecular layer (Mol. L.); Grl. L.: granular layer; antibody: 3F4; dis. durat.: disease duration