Hypoxic oligodendrocyte precursor cell-derived VEGFA is associated with blood–brain barrier impairment

Table 2 Association between increased VEGFA plasma levels and BBB leakage rate in the NAWM of cSVD patients

		Univariable		Multivariable (age and sex corrected)
		β [95%CI]	p-value	β [95%CI]	p-value
WMH		− 0.024 [− 0.324, 0.276]	0.873	0.009 [− 0.277, 0.294]	0.951
BBB leakage in NAWM	K_i	0.286 [− 0.001, 0.574]	0.051	0.307 [0.009, 0.605]	0.044
	v_L	− 0.217 [− 0.510, 0.076]	0.142	− 0.255 [− 0.556, 0.045]	0.093
BBB leakage in WMH	K_i	0.286 [− 0.001, 0.574]	0.051	0.284 [− 0.016, 0.585]	0.063
	v_L	− 0.170 [− 0.466, 0.126]	0.253	− 0.208 [− 0.511, 0.095]	0.174

Univariable analysis was conducted with MRI characteristics as dependent and VEGFA as independent variable. Multivariable analysis was done by correcting for age and sex. Standardised Coefficients Beta (β) with the estimated 95% confidence interval (95%CI) and p-value are shown for each analysis. P < 0.05 was considered significant
WMH white matter hyperintensities, BBB blood–brain barrier, NAWM normal appearing white matter, K_i leakage rate, v_L leakage volume, CI confidence interval

ISSN: 2051-5960