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Table 1 Characteristics of the clinical study population

From: Hypoxic oligodendrocyte precursor cell-derived VEGFA is associated with blood–brain barrier impairment

  

Controls (n = 26)

cSVD Patients (n = 47)

Univariable

Multivariable (age and sex corrected)

β (p-value)

β (p-value)

 

Age (years)

67.8 ± 2.5

69.6 ± 1.6

  
 

Male (Female)

18 (8)

30 (17)

  

WMH

Relative volume, 10–3

3.5 ± 1.8

16.1 ± 2.4

0.390 (< 0.001)

0.412 (< 0.001)

BBB leakage in NAWM

Ki, 10−3 min−1

1.09 ± 0.07

0.98 ± 0.05

 − 0.176 (0.137)

 − 0.182 (0.129)

 

vL

0.276 ± 0.034

0.370 ± 0.028

0.241 (0.040)

0.253 (0.035)

BBB leakage in WMH

Ki, 10−3 min−1

0.85 ± 0.06

0.84 ± 0.04

 − 0.016 (0.893)

 − 0.033 (0.723)

 

vL

0.318 ± 0.037

0.459 ± 0.031

0.318 (0.006)

0.328 (0.005)

  1. Characteristics in mean ± SEM unless otherwise indicated. Association between WMH, BBB leakage rate (Ki) and volume (VL) and participant group was determined using a uni- and multivariable (corrected for age and sex) analysis. Standardised Coefficients Beta (β) and p-value are shown for each analysis. P < 0.05 was considered as significant
  2. WMH white matter hyperintensities, BBB blood–brain barrier, NAWM normal appearing white matter, Ki leakage rate, vL leakage volume
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Acta Neuropathologica Communications

ISSN: 2051-5960

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