Fig. 1
Bilateral carotid artery stenosis led to a persistent decrease in cerebral blood flow. (A) LSCI images showing blood flow in superficial blood vessels captured at baseline, d0, and d7. Blood flow measurements in ROI1 (blue) contained all sizes superficial blood vessels, while ROI2 (red) contained the 3rd order branch from superior sagittal sinus to avoid larger superficial vessels. Visualization of blood flow signal ranged from high flow (red) to low flow (blue). (B) Changes in CBF were quantified and compared to baseline measurements at d0 and d7 (ROI2). Scale bar, arbitrary value, 150 (low blood flow), 800 (high blood flow). Mean ± SEM; ns = not significant; #p < 0.05, ##p < 0.01 vs baseline measurements; **p < 0.01, vs Sham; unpaired student t-test