APOE-ε4 and BIN1 increase risk of Alzheimer’s disease pathology but not specifically of Lewy body pathology

Table 5 Association of rs4663105 on the BIN1 locus with different pathology contrasts

	Current study	Initial sample × Tsuang et al. [51] criteria	Initial sample × Kaivola et al. [27] criteria	Reported by Chia et al. [13] (at rs6733839)^a
AD⁺LB⁺ vs. AD^–LB^–	1.53 [1.35 1.75] (1.35e−10)	1.55 [1.35 1.77] (2.19e−10)	1.56 [1.33 1.82] (1.99e−08)	N/A
AD⁺LB^– vs. AD^–LB^–	1.40 [1.26 1.56] (6.51e−10)	1.36 [1.23 1.51] (4.45e−09)	1.36 [1.22 1.52] (6.32e−08)	N/A
AD^–LB⁺ vs. AD^–LB^–	1.10 [0.85 1.41] (4.76e−01)	1.20 [1.00 1.44] (4.81e−02)	1.11 [0.86 1.43] (4.18e−01)	N/A
AD⁺LB⁺ vs. AD⁺LB^–	1.13 [1.02 1.25] (1.91e−02)	1.14 [1.03 1.28] (1.57e−02)	1.20 [1.07 1.35] (2.10e−03)	N/A
LB⁺ vs. AD^–LB^–	N/A	N/A	N/A	1.25 [1.16 1.35] (4.16e−09)

The first column corresponds to the current study, while the following two columns correspond to results obtained using the current sample using literature criteria to classify participants into pathology groups (Fig. 1a–b) [27, 51]. The last column corresponds to a result reported in the literature [13]. Effect sizes are reported as OR with 95% confidence interval [CI] and significance (P-value)
^ars4663105 and rs6733839 reported in [13] are in linkage disequilibrium (R² = 0.8968)

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