Fig. 2

Manhattan plots of genetic association with pathology contrasts. a. Association with AD⁺LB⁺ pathology versus AD^–LB^– pathology. b. Association with AD⁺LB^– pathology versus AD^–LB^– pathology. c. Association with AD^–LB⁺ pathology versus AD^–LB^– pathology. d. Association with AD⁺LB⁺ pathology versus AD⁺LB^– pathology. Variants at two novel loci exhibited genome-wide significant associations in the AD^–LB⁺ versus AD^–LB^– analysis (rs112017605 on both an intron of AC024598.1 and an intron of AC067752.1 on chromosome 10 and rs116691607 on an intron of BLMH on chromosome 17) (c; Additional file 1: Table S2), but we do not discuss these candidates in the main text because neither was flanked by a set of nearby variants in linkage disequilibrium, raising concern that these could be spurious signals