Table 2 Summary of animals used in APOE genotype study
APOE genotype study | |||
|---|---|---|---|
Animal model | TgM83+/− (BL6) | APOE ε3+/+/TgM83+/− | APOE ε4+/+/TgM83+/− |
Cohorts | PFF-injected; n = 8 (6F:2M) | PFF injected; n = 12 (6F:6M) | PFF injected; n = 12 (6F:6M) |
PBS injected; n = 12 (6F:6M) | PBS injected; n = 7 (3F:4M) | ||
Type/amount of injection | 5 µg of human αSyn PFFs in 5 µl PBS; or PBS | ||
Age of injection | 2 months | ||
Region of injection | Unilateral injection in right gastrocnemius muscle | ||
Age at harvest | 8 months post-injection unless motor impaired | ||
Total n | 51 | ||