Table 1 Summary of animals used in time-course study
Time-course study | |
|---|---|
Animal model | TgM83+/− (C3H/BL6) |
Cohorts | 1 m.p.i.; n = 8 (4F:4M) |
2 m.p.i.; n = 9 (5F:4M) | |
3 m.p.i.; n = 8 (4F:4M) | |
Aged until paralysis; n = 8 (5F:3M) | |
naïve; n = 5 (4F:1M) | |
Type/amount of injection | 10 µg of mouse αSyn PFFs in 5 µl PBS (20 µg total); or PBS |
Age of injection | 2 months |
Region of injection | Bilateral injection in gastrocnemius muscle |
Age at harvest | 1 m.p.i., 2 m.p.i., 3 m.p.i. and at onset of motor impairment |
Total n | 38 |