Skip to main content
Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Carboxyl truncation of α-synuclein occurs early and is influenced by human APOE genotype in transgenic mouse models of α-synuclein pathogenesis

Fig. 6

Regionally dynamic αSynΔC immunoreactive pathology is differentially regulated by APOE genotype. The burden of αSynΔC positive inclusions in the spinal cord, medulla, pons, midbrain, hypothalamus, thalamus, cortex and striatum of PFF-injected M83+/−, APOE ε4+/+/M83+/− and APOE ε3+/+/M83+/− mice were scored by 3 independent observers. Averaged scores were normalized to 81A (pSer129) and analyzed using 2-way ANOVA and corrected using Tukey’s multiple comparisons test. Data represents means +/− SEM. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001

Back to article page

Acta Neuropathologica Communications

ISSN: 2051-5960

Contact us