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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Carboxyl truncation of α-synuclein occurs early and is influenced by human APOE genotype in transgenic mouse models of α-synuclein pathogenesis

Fig. 1

Schematics of experimental designs assessing the spatiotemporal progression of αSyn inclusion pathology including various αSynΔC forms. (a) Representative illustration of experimental design showing IM injection of PFFs and theorized route of spatiotemporal pathological propagation of αSyn type prion transmission. (b) Stick diagrams of peptide sequences used to generate αSynΔC specific αSyn antibodies. Antibodies are not drawn to scale. Structural model is based on PDB accession 1XQ8. Created with Biorender.com

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Acta Neuropathologica Communications

ISSN: 2051-5960

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