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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: MGMT methylation pattern of long-term and short-term survivors of glioblastoma reveals CpGs of the enhancer region to be of high prognostic value

Fig. 6

Analyzed CpGs of MGMT and correlation with other studies. The analyzed CpGs of the current study starting from CpG 23 (bp -300) to CpG 101 (bp + 309) and selected previous studies are highlighted in blue. The relative position to the transcription start site (TSS) are given. Primers that cover the area included in this study comprise Prom (gray), E1I1 (brown), ATG1 (yellow). Regions of MGMT are depicted as follows: minimal promoter (light green), exon1 (turquoise), enhancer (pink) CpG site 51, which has been disregarded by some authors, is highlighted in red. CpG sites that were linked to increased overall survival are highlighted in orange. CpGs with increased overall survival in our study highlighted in orange were chosen based on Random Forest analysis without imputed data

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Acta Neuropathologica Communications

ISSN: 2051-5960

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