Fig. 4

Conditional Random Forest of CpGs 75–101 of MGMT. Conditional Random Forest analysis including CpGs 75–101 as well as temozolomide, age at diagnosis, lobe and hemisphere. Random Forest analysis including imputed data revealed increased signals in the area of CpGs 75–79, CpGs 84–88 as well as at CpGs 94–96. Temozolomide treatment was the factor with the highest signal and, therefore, demonstrated the strongest correlation with outcome. CpG 86 (bp + 154) showed the second highest value followed by age at diagnosis