Table 2 Enrichment of co-regulated 5hmC and transcriptomic modules by phenotype
Module Type | Module | Number of Features | Control NES (FDR) | GBM NES (FDR) | IDH1-Mut astrocytoma NES (FDR) |
|---|---|---|---|---|---|
5hmC–mRNA | M1 | 367 | 5.59 (0) | − 5.23 (0) | 0.87 (0.88) |
M2 | 68 | − 4.91 (0) | 5.12 (0) | − 2.78 (0) | |
M3 | 66 | 2.13 (0) | − 2.53 (0) | 2.65 (0) | |
M4 | 40 | − 4.59 (0) | 4.18 (0) | 1.31 (0.113) | |
M5 | 38 | − 4.48 (0) | 4.3 (0) | − 1.49 (0.063) | |
5hmC only | M1 | 213 | − 0.92 (0.771) | 0.99 (0.6) | − 1.15 (0.155) |
M2 | 181 | − 2.43 (0) | 1.49 (0.005) | 1.72 (0) | |
M3 | 106 | 3.42 (0) | − 3.22 (0) | 2.11 (0) | |
M4 | 97 | − 1.85 (0) | 1.77 (0.001) | − 1.19 (0.155) | |
M5 | 77 | − 2.41 (0) | 3.07 (0) | − 2.91 (0) | |
M6 | 54 | 2.69 (0) | − 2.34 (0) | 1.54 (0.032) | |
Transcripts only | M1 | 463 | 6.48 (0) | − 6.54 (0) | 1.29 (0.009) |
M2 | 92 | − 4.49 (0) | 4.93 (0) | − 2.63 (0) | |
M3 | 89 | − 5.17 (0) | 4.74 (0) | 1 (0.445) | |
M4 | 53 | − 4.65 (0) | 4.49 (0) | − 1.83 (0.001) | |
M5 | 40 | − 2.63 (0) | − 2.04 (0.001) | 2.45 (0) |