Fig. 4

Prognostic significances of co-regulated modules and prediction models. A Forest plots showing hazard ratios (HR) of different co-regulated modules. Kaplan–Meier survival curves demonstrating significant differences between B IDH1-WT (GBM) and IDH1-Mut astrocytoma tumors; C low- and high-risk groups categorized based on mRNA–mRNA co-regulated modules derived CMPS; D low- and high-risk groups categorized based on 5hmC–5hmC co-regulated modules derived CMPS; E low- and high-risk groups categorized based on 5hmC–mRNA co-regulated modules derived CMPS. F Time-dependent ROC curves for patients’ survival with AUC measures evaluated using 5hmC co-regulated modules derived CMPS. G ROC curves for patients’ survival with AUC measures evaluated using 5hmC–mRNA co-regulated modules derived CMPS