DNA methylation, combined with RNA sequencing, provide novel insight into molecular classification of chordomas and their microenvironment

Table 3 Survival effect of selected clinical and molecular features in a uni- and multivariate Cox hazard model

Variable	Trait	Multivariate			Univariate
Variable	Trait	Coefficient	Z	p value	Coefficient	Z	p value
CNVs		0.16	2.92	0.003	0.08657	3.05	0.002
Immune infiltrate		6.70	1.60	0.11	− 2.32	− 1.06	0.29
Sex	Male	− 1.12	− 1.45	0.15	0.05	1.84	0.07
Age		0.04	1.40	0.16	− 0.45	− 0.77	0.44
Cluster	Chordoma I	0.60	0.61	0.54	− 0.32	− 0.52	0.60
		Likelihood ratio test = 15.56 on 5 degrees of freedom, p = 0.008 events: 13 of 31 observations

ISSN: 2051-5960