Fig. 4
In vivo effects of ITGA5 KD in HD-MB03-Re. (A) Representative H&E-stained sections of brains isolated from mice xenografted with HD-MB03 lentivirally transduced with shITGA5-4 construct vs. shGFP (control). Samples were compared at endpoint of control animal to allow for time-matched comparison. (B) Quantification of tumor burden (mm2) of time-matched specimens (C) Kaplan-Meier survival of mice engrafted of control vs. ITGA5 KD in HD-MB03-Re.