Fig. 1

Identification of ITGA5 as a highly expressed cell surface glycoprotein in Group 3 MB relapse. (A) Schematic representation of the glycocapture enrichment protocol of patient-derived human Group 3 MB samples. Established PDX mouse-adapted therapy model enabled isolation of brain samples at engraftment (ENG), control (CTRL), post-radiation (R), post-radiation and chemotherapy (RC), and relapse (Re). (B) Sequential steps to identify cell surface proteins enriched at relapse. (C) Top 14 cell surface glycoproteins highly expressed in relapse, but not expressed in engraftment and control samples; common logarithmic (Log10) scale used