Fig. 4

Perivascular mesenchymal stromal cells (pMSC) in normal brain and in glioblastoma. In normal brain, pMSC form the neurovascular unit, together with endothelial cells, astrocytes, and neurons. The neurovascular unit supplies nutrients and oxygen through the blood brain barrier. In glioblastoma (GB), resident pMSC and glioma stem cell-differentiated pMSC participate in vascular proliferation. Leaving the vessel, pMSC may give rise to GB stem cells, GB cells, and cancer-associated fibroblasts. (MPZ: Myelin P zero) (created with Biorender.com)