Table 3 Top 10 significantly differentially expressed proteins in the white matter of the pons in VWM
From: Regional vulnerability of brain white matter in vanishing white matter
Direction | Gene symbol | Protein name | Log2 (Fold change) | q-value |
|---|---|---|---|---|
Upregulated | ANXA1 | Annexin A1 | 5.475 | 0.000533 |
Upregulated | FLNC | Filamin-C | 5.153 | 0.002169 |
Upregulated | NES | Nestin | 4.832 | 0.002385 |
Upregulated | SCIN | Adseverin | 4.397 | 0.003139 |
Upregulated | C12orf10 | UPF0160 protein MYG1, mitochondrial | 4.229 | 0.007986 |
Upregulated | PREP | Prolyl endopeptidase | 4.177 | 0.000053 |
Upregulated | SERPINA1 | Alpha-1-antitrypsin;Short peptide from AAT | 3.782 | 0.029830 |
Upregulated | IQGAP1 | Ras GTPase-activating-like protein IQGAP1 | 3.509 | 0.002169 |
Upregulated | FGA | Fibrinogen alpha chain;Fibrinopeptide A;Fibrinogen alpha chain | 3.242 | 0.014698 |
Upregulated | COL6A3 | Collagen alpha-3(VI) chain | 3.031 | 0.030125 |
Downregulated | ATP6V1G2 | V-type proton ATPase subunit G 2 | -2.784 | 0.019741 |
Downregulated | NCAN | Neurocan core protein | -2.842 | 0.000796 |
Downregulated | VCAN | Versican core protein | -2.935 | 0.000796 |
Downregulated | SVIP | Small VCP/p97-interacting protein | -2.958 | 0.004164 |
Downregulated | ATPIF1 | ATPase inhibitor, mitochondrial | -3.278 | 0.005709 |
Downregulated | COX7C | Cytochrome c oxidase subunit 7Â C, mitochondrial | -3.412 | 0.000076 |
Downregulated | AQP1 | Aquaporin-1 | -3.502 | 0.001082 |
Downregulated | PMP2 | Myelin P2 protein | -4.073 | 0.003569 |
Downregulated | NIN | Ninein | -5.611 | 0.000069 |
Downregulated | SYP | Synaptophysin | -6.191 | 0.000174 |