Table 2 Top 10 significantly differentially expressed proteins in the white matter of the frontal lobe in VWM
From: Regional vulnerability of brain white matter in vanishing white matter
Direction | Gene symbol | Protein name | Log2 (Fold change) | q-value |
|---|---|---|---|---|
Upregulated | BSN | Protein bassoon | 5.233 | 0.000258 |
Upregulated | ATP6V0A1 | V-type proton ATPase 116Â kDa subunit a isoform 1 | 5.123 | 0.000258 |
Upregulated | L1CAM | Neural cell adhesion molecule L1 | 4.688 | 0.000096 |
Upregulated | SV2A | Synaptic vesicle glycoprotein 2Â A | 4.443 | 0.000550 |
Upregulated | SYNM | Synemin | 4.354 | 0.000733 |
Upregulated | NPTN | Neuroplastin | 4.311 | 0.000086 |
Upregulated | ATP2B1 | Plasma membrane calcium-transporting ATPase 1 | 4.254 | 0.000875 |
Upregulated | PSD3 | PH and SEC7 domain-containing protein 3 | 4.137 | 0.007253 |
Upregulated | RAB3D | Ras-related protein Rab-3D | 4.039 | 0.004826 |
Upregulated | COL6A3 | Collagen alpha-3(VI) chain | 3.861 | 0.004865 |
Downregulated | LGALS1 | Galectin-1 | -3.664 | 0.001022 |
Downregulated | GLUL | Glutamine synthetase | -3.666 | 0.003525 |
Downregulated | ALDH4A1 | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial | -3.709 | 0.000707 |
Downregulated | OXR1 | Oxidation resistance protein 1 | -3.736 | 0.003678 |
Downregulated | VCAN | Versican core protein | -3.771 | 0.000096 |
Downregulated | PRDX6 | Peroxiredoxin-6 | -3.798 | 0.000096 |
Downregulated | BASP1 | Brain acid soluble protein 1 | -3.996 | 0.000179 |
Downregulated | ERMN | Ermin | -4.115 | 0.000096 |
Downregulated | GLTP | Glycolipid transfer protein | -4.185 | 0.000258 |
Downregulated | ALDH7A1 | Alpha-aminoadipic semialdehyde dehydrogenase | -5.528 | 0.000258 |