Fig. 8

Functional and pathway analysis proteins distinct for VWM pons white matter. (a) Gene ontology and (b) KEGG pathway analysis of proteins downregulated (n = 72) and upregulated (n = 111) in only the VWM pons white matter. In (a), only the most specific ontology subclasses are shown. In (a-b), red and blue bars represent terms associated with higher and lower expressed proteins, respectively. Number of proteins annotated in each term is listed in the plot. Fold enrichment values below 1 represent underrepresented terms, whereas a value above 1 represents overrepresented terms. EWCE analysis of the (c) upregulated and (d) downregulated proteins shows that only proteins with higher expression are associated with specific cell types in the pons white matter of VWM patients. * q-value < 0.05, **** q-value < 0.0001, S.D. standard deviation, OPCs oligodendrocyte progenitor cells