Fig. 7
From: Regional vulnerability of brain white matter in vanishing white matter
Functional and pathway analysis of proteins distinct for VWM frontal white matter. (a) Gene ontology and (b) KEGG pathway analysis of proteins downregulated (n = 267) and upregulated (n = 191) in only the VWM frontal white matter. In (a), only the most specific ontology subclasses are shown. In (a-b), red and blue bars represent terms associated with higher and lower expressed proteins, respectively. Number of proteins annotated in each term is listed in the plot. Fold enrichment values below 1 represent underrepresented terms, whereas a value above 1 represents overrepresented terms. EWCE analysis of the (c) upregulated and (d) downregulated proteins confirms involvement of distinct cell types in the frontal white matter of VWM patients. * q-value < 0.05, ** q-value < 0.01, *** q-value < 0.001, **** q-value < 0.0001, S.D. standard deviation, OPCs oligodendrocyte progenitor cells