Fig. 6

Identifying the overlap of significantly differentially expressed proteins in the VWM frontal and pons white matter. (a) Significantly differentially expressed proteins in the VWM frontal (n = 498 proteins) and pons (n = 224 proteins) white matter were compared. Seventy-two proteins were shared between regions. Of these, expression of 40 proteins changed in the same direction (blue), whereas 32 changed in the opposite direction (pink). A total of 426 (green) and 152 (purple) proteins were altered in only the VWM frontal and pons white matter, respectively. (b) Correlation analysis of all significantly differentially expressed proteins in the VWM frontal and pons white matter reveals little similarities (R² = 0.0177). Significantly altered proteins are highlighted according to the colors in (a), and proteins not significantly altered are shown in gray