Fig. 4
From: Regional vulnerability of brain white matter in vanishing white matter
Proteome pattern of the pons white matter in VWM. (a) Differential expression analysis reveals proteome differences in the pons white matter of controls compared to VWM patients. Volcano plot shows proteins with significantly lower (blue, left) or higher (red, right) expression in VWM pons white matter (q-value < 0.05). Not significantly differentially expressed proteins (q-value > 0.05) are colored in gray. (b) EWCE analysis suggests that upregulated proteins in the pons white matter of VWM patients are associated with distinct cell types. * q-value < 0.05, *** q-value < 0.001, S.D. standard deviation, OPCs oligodendrocyte progenitor cells