Fig. 2

Proteome pattern of the frontal white matter in VWM. (a) Differential expression analysis reveals proteome differences in the frontal white matter of controls compared to VWM patients. Volcano plot shows proteins with significantly lower (blue, left) and higher (red, right) expression in the VWM frontal white matter (q-value < 0.05). Not significantly differentially expressed proteins (q-value > 0.05) are colored in gray. (b) EWCE analysis indicate that lower (blue, left) and higher (red, right) expressed proteins in the frontal white matter of VWM patients are associated with distinct cell types. * q-value < 0.05, ** q-value < 0.01, *** q-value < 0.001, **** q-value < 0.0001, S.D. standard deviation, OPCs oligodendrocyte progenitor cells