Fig. 1

Principal component analyses of the white matter in the frontal lobe and pons in control and VWM cases. (a) Analysis of the frontal white matter shows that the first component separates control cases (black) from VWM cases (pink) and accounts for 49.0% of the variability. The second component reveals segregation between VWM cases and explains 17.7% of the variability. (b) Analysis of the pons white matter reveals separation of VWM patients (pink) and controls (black) in the first component, explaining 46.4% of the variability. Only one patient sample deviates from the patient group as revealed by the second component. This accounts for 23.2% of the variability. All controls aggregated together across regions. PC1 principal component 1, PC2 principal component 2, Ctrl control, VWM vanishing white matter