Fig. 5

Functional connectivity from the HC to the PFC is impaired in PD abstinent rats as compared to controls. (A) Representative evoked potentials in the PFC and PS in CA1 in response to stimulation in control (black) and PD (orange) animals, overlaid on a schematic representation of the respective structures. (B) Group level quantification of the amplitude of the evoked potentials in the PFC from control and PD rats. (C) Effective connectivity between the HC and PFC measured as the evoked response in the PFC divided by the corresponding CA1 PS amplitude (input/output ratio). Box-and-whisker plot showing the first and third quartile (box) and min/max values (whiskers). The horizontal line in the box represents the median. Asterisks represents significant difference in the unpaired t-test statistic (*p < 0.05, **p < 0.01). (D-E) Spectral coherence (D) and broad band cross-correlation analysis (E) between CA1 and PFC spontaneous recordings in 19 control (black) and 18 PD (orange) rats. The inset shows representative spontaneous LFP traces recorded in CA1 (pyramidal layer) and PFC (prelimbic region). Scale bar in spontaneous LFPs: 1mV, 0.5ms