Fig. 6

Mature oligodendrocyte numbers increase to a similar extent in WT and Abcd1 KO mice upon cuprizone withdrawal. (a) Representative images of immunohistochemistry for in the corpus callosum of WT and Abcd1 KO mice during recovery from 5 weeks cuprizone intoxication show mature (CAII⁺) oligodendrocytes (a) and of APP⁺ spheroids marking acute axonal damage (c). Scale bar: 100 µm. (b), (d) Quantifications of (a) and (c), respectively. Statistical analysis: One-way ANOVA with Sidak’s multiple comparisons test (n = 6–10 WT; 6–8 Abcd1 KO mice). For APP 5 days off CPZ, adjusted p-value: *p = 0.0353