Fig. 1

Overview of diagnostic reclassification of original histopathological ependymoma diagnoses following tumor methylation profiling. In Sturm et al.’s study, six additional children were reclassified from other non-ependymoma tumor types to ependymoma following tumor methylation profiling (not shown). Targeted germline sequencing was performed for five without detection of pathogenic variants. Adapted from Foss-Skiftesvik et al. Acta Neuropathologica Communications(2022) 10:123, https://doi.org/10.1186/s40478-022-01429-1 with permission under the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/). Created with BioRender.com