Fig. 3From: Correction: Differential effects of mutations of POPDC proteins on heteromeric interaction and membrane traffickingThe expression of POPDC1 and POPDC2 is greatly reduced at the sarcolemma of skeletal muscle fibers expressing POPDC1 p.Q153X. a and b Transverse sections of skeletal muscle biopsies from a patient (PT) carrying the POPDC1 p.Q153X variant in homozygosity and a matched control (CT) were stained for a POPDC1 or b POPDC2, along with SGCA as a sarcolemma marker. Scale bar: 100 μm. c and d The expression levels of c POPDC1 and d POPDC2 in the sarcolemma normalized to SGCA, were quantified in individual fibers. The number of sections (sec), images (img) and fibers (fib) analyzed per group are as follows: CT: POPDC1—1 s, 4 img, 238 fib; POPDC2—1 s, 4 img, 163 fib. PT: POPDC1—1 s, 3 img, 65 fib; POPDC2—1 s, 3 img, 70 fib. The median POPDC/SGCA-level in each control biopsy was set to 1. Dashed lines indicate the normalized median and interquartile range. Data were analyzed using Mann–Whitney test; ****p < 0.0001Back to article page