Fig. 6
From: Presymptomatic and early pathological features of MAPT-associated frontotemporal lobar degeneration
Staging of grey and white matter tau pathology across clinicopathological stages in the P301L variant
Plots portray regional progression of grey (a) and white (b) matter pathology across clinicopathological stages in the P301L variant
Legend: %AO = percentage of area occupied (by tau-positive pixels); ACC = anterior cingulate cortex; AMY = amygdala; aSLF = anterior superior longitudinal fasciculus; ATC = anterior temporal cortex; CA1 = cornu ammonis 1; CAU = caudate nucleus; GD = gyrus dentatus; IC = internal capsule; IPL = inferior parietal lobule; MFC = middle frontal cortex; pSLF = posterior superior longitudinal fasciculus; SUB = subiculum; TEC = transentorhinal cortex
Tau burden (y-axis, a-b) corresponds to the digitally measured %AO by tau pathology after applying natural logarithmic transformation