Fig. 6
C5aR1 antagonist PMX205 reduces immune cell recruitment to injured hemisphere but has no impact on neurological outcomes following TBI. A Summary of C5aR1 expression by the 13 immune cell types identified by CyTOF. Non-significant changes (compared to the sham group) are in gray. B Graphical summary of the PMX205 experiment. Injured groups received PBS or PMX205. Sham (control) group was included. C Total number of CD45high cells (immune cells) extracted from the injured brain hemispheres in cohort 1 and quantified by flow cytometry. N = 9–10 per group. D–I Summary of the behavioral outcomes and lesion volume over 28 days after TBI. N = 8–10 per group. C–I Data are shown as mean ± SEM. *p < 0.05. False discovery rate was used to adjust the p-value in panel A. Repeated measures ANOVA was used in panel D. Bonferroni correction was used for multiple comparisons in the panels. Abbreviations: cDC = conventional dendritic cell, pDC = plasmacytoid dendritic cell, MdC = monocyte-derived cell