Fig. 3

Bulk RNAseq analysis of the forebrains of APOE homozygous mice. Differentially regulated genes from APOE2, APOE3 and APOE4 homozygous mice are presented in a heat map (A). Volcano plot of DEG and GO and KEGG pathway analysis of enriched gene sets are shown for E2H vs E3H mice (B–D), E4H vs E3H mice (E–G), and E4H vs E2H mice (H–J). Asterisks in volcano plot refer to predicted genes. The bubble plots are colored by p-value and sized by number of genes in enriched gene sets, as defined in the accompanying panel. N = 3 mice/group