Fig. 2

Gliosis levels in PS19 mice homozygous for APOE2, APOE3 or APOE4. PS19 mice homozygous for APOE allele were aged until they exhibited bilateral hindlimb paralysis and analyzed for microgliosis (A) and astrocytosis (B) in the forebrain. Representative immuno-stained images and corresponding quantification of Iba-1 and GFAP immunostaining (% immunoreactivity) in the cortex and hippocampus are shown. (n = 9 (PS/E2H), 7 (PS/E3H), 16 (PS/E4H).1-way ANOVA *p < 0.05, **p < 0.01. Scale bar: 100 µm