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Fig. 9 | Acta Neuropathologica Communications

Fig. 9

From: Senescence-related impairment of autophagy induces toxic intraneuronal amyloid-β accumulation in a mouse model of amyloid pathology

Fig. 9

The brains of AD patients present altered autophagy. a Western blot analysis showing LC3 and p62 relative protein levels in the SDS-soluble fraction of homogenates derived from temporal cortex of non-AD, p-preAD and AD cases. GAPDH was used as loading control, and the levels in the control group were set as 100%. *P < 0.05, **P < 0.01, ***P<0.001 (One-way ANOVA with Tukey’s post-hoc analysis, n = 5 patients/group). Data are presented as mean ± SEM. b DAB immunostainings against LC3 and p62 in the CA1 hippocampal region of representative non-AD, p-preAD and AD cases. Scale bar: 50 μm or 10 μm (magnified image). non-AD: non-demented control; p-preAD: pathologically defined preclinical AD; AD: symptomatic AD

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Acta Neuropathologica Communications

ISSN: 2051-5960

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