Neurodegenerative pathologies associated with behavioral and psychological symptoms of dementia in a community-based autopsy cohort

Table 7 Odds ratio and 95% confidence intervals (OR and 95% CI) of having moderate or severe BPSD (scored 2 or 3 on 0–3 scale), stratified by pathology, in cases with Braak NFT stage < V and relatively pure subtypes of pathology

Symptom readout	LATE-NC only versus control		Neocortical Lewy bodies only versus control		Vascular pathology^a only versus control
Symptom readout	OR (95% CI)	p value^b	OR (95% CI)	p value^b	OR (95% CI)	p value^b
CDR-Global	4.3 (1.6–11.9)	0.004	1.0 (0.2–4.3)	0.96	11.9 (2.7–86)	0.003
CDR-Language	1.5 (0.2–7.3)	0.64	N/A^d	N/A^d	9.7 (1.4–199)	0.048
NPI-Q: Psychosis^c	2.6 (0.7–8.7)	0.14	2.9 (0.6–12.5)	0.16	3.1 (0.7–14.3)	0.13
NPI-Q: Agitation	1.6 (0.5–4.6)	0.40	1.2 (0.3–4.1)	0.79	1.7 (0.5–5.1)	0.36
NPI-Q: Depression	1.1 (0.4–2.9)	0.84	2.8 (1.0–7.4)	0.041	1.2 (0.4–3.3)	0.69
NPI-Q: Anxiety	0.9 (0.2–2.8)	0.89	1.2 (0.3–3.7)	0.77	1.4 (0.5–4.0)	0.48
NPI-Q: Apathy	2.9 (1.2–7.1)	0.021	0.8 (0.2–2.6)	0.71	1.7 (0.6–4.6)	0.30
NPI-Q: Disinhibition	2.0 (0.5–6.8)	0.30	N/A^d	N/A^d	3.9 (1.1–16.4)	0.043
NPI-Q: Irritability	2.0 (0.6–5.7)	0.21	0.7 (0.1–2.9)	0.66	2.3 (0.8–7.1)	0.14
NPI-Q: Motor	7.0 (1.7–31.6)	0.008	2.7 (0.4–14.5)	0.26	3.5 (0.5–29.4)	0.20
NPI-Q: Appetite	0.5 (0.1–1.8)	0.36	0.2 (0.0–1.2)	0.17	1.3 (0.5–3.5)	0.63

^a“Vascular pathology” describes cases where it was deemed likely that cerebrovascular disease was severe enough to contribute to cognitive impairment
^bp < 0.05 in bold
^c“Psychosis” combines the NPI-Q fields of delusions and hallucinations
^dIn several categories (indicated by “N/A”), the sample sizes were too small to perform valid statistical tests

ISSN: 2051-5960