Severe CTE and TDP-43 pathology in a former professional soccer player with dementia: a clinicopathological case report and review of the literature

Table 3 Literature review (pathological features)

Case #	Septum	CTE severity	ABC score (+ ADNC)	TDP-43	α-syn	Other pathological diagnoses
1	Unknown	Low	Unknown	Present	Unknown	MND
2	Unknown	Unknown	Unknown^a	Present	Unknown	–
3	CSP	High	A1B2C3 (intermediate)	Present	Absent	Hippocampal sclerosis
4	CSP + F	Unknown	A3B2C2 (intermediate)	Present	Absent	CBD, CAA
5	F	Unknown	A2B2C2 (intermediate)	Present	Absent	Hippocampal sclerosis
6	F	Unknown	A2B2C2 (intermediate)	Present	Absent	CAA, Hippocampal sclerosis
7	F	Unknown	A3B2C2 (intermediate)	Present	Absent	CAA
8	CSP	Unknown	Unknown	Unknown	Unknown	Unknown
9	CSP + F	High	A1B2C0 (low)	Absent	Absent	CVD, CAA
10	CSP	High	A0B2C0 (none)	Present	Absent	CVD; PART
11	F	High	A2B3C3 (intermediate)	Absent	Present	DLB, CAA
12	Unknown	High	A3B3C2 (high)	Present	Absent	CVD; ARTAG
13	CSP	Low	A3B3C2 (high)	Present	Present	CVD; DLB; ARTAG; CAA
14	CSP + F	High	A1B3C0 (low)	Present	Absent	Hippocampal sclerosis, FTLD, CVD, ARTAG, PSP

An overview of the pathological findings of soccer players with pathology-confirmed CTE
^aReport mentioned that amyloid plaques and neuritic plaques were present but to a lesser extent
CTE chronic traumatic encephalopathy, ADNC Alzheimer’s disease neuropathological change, CSP cavum septum pellucidum, F fenestration of septum, MND motor neuron disease, CBD corticobasal degeneration, CAA cerebral amyloid angiopathy, CVD cerebrovascular disease, DLB dementia with Lewy Bodies, PART primary age-related tauopathy, ARTAG aging-related tau astrogliopathy, PSP progressive supranuclear palsy

ISSN: 2051-5960