Fig. 3

Signs of lysosomal storage material in frontal cortex of patients with FTD-GRN or sporadic FTLD-TDP type A. Patients with FTD-GRN exhibited a greater number of autofluorescent particles than controls in frontal cortex (ANOVA effect of group, p = 0.0243), while patients with sporadic FTLD-TDP type A did not differ from controls. c No difference was detected in autofluorescent particles in the occipital cortex of either group versus control (ANOVA effect of group, p = 0.4988). d, e Patients with FTD-GRN also exhibited a greater number of Sudan Black B-positive particles than controls in frontal cortex (ANOVA effect of group, p = 0.0022), as did patients with sporadic FTLD-TDP type A. f Levels of Sudan Black B-positive particles in occipital cortex of patients with FTD-GRN or FTLD-TDP type A did not significantly differ from controls (ANOVA effect of group, p = 0.0819). Scale bars in a, d represent 50 μm. *p < 0.05 and ***p < 0.001 by Fisher’s LSD post-hoc test. n = 5 controls, 13 patients with FTD-GRN, and 7 patients with sporadic FTLD-TDP type A