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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Patients with sporadic FTLD exhibit similar increases in lysosomal proteins and storage material as patients with FTD due to GRN mutations

Fig. 2

Similar changes in lysosomal gene expression in patients with FTD-GRN and sporadic FTLD-TDP type A. a Nanostring analysis of 42 genes related to endolysosomal function revealed similar changes in gene expression in frontal cortex of patients with FTD-GRN and patients with sporadic FTLD-TDP type A. b, c Statistical analysis revealed 20 differentially expressed genes versus control in frontal cortex across both patient groups, with no significant changes versus control in occipital cortex. c, d There was strong overlap of differentially expressed genes across both patient groups, with 16/20 genes exhibiting altered expression in both groups. Shaded cells in c indicate statistical significance after correction for multiple comparisons. n = 5 controls, 12 patients with FTD-GRN, and 7 patients with sporadic FTLD-TDP type A. In a GRN = FTD-GRN and TDP-A = FTLD-TDP type A

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Acta Neuropathologica Communications

ISSN: 2051-5960

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