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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: The G51D SNCA mutation generates a slowly progressive α-synuclein strain in early-onset Parkinson’s disease

Fig. 1

Inoculation of G51D PD and MSA samples into TgM83+/- mice. a Immunoblots of total α-syn, detergent-soluble α-syn, detergent-insoluble α-syn, and detergent-insoluble PSyn species in brain homogenates from the G51D PD-1, G51D PD-2, and MSA-1 cases. α-Syn was detected using the antibody Syn-1 and PSyn was detected using the antibody EP1536Y. b Schematic of propagation studies in TgM83+/- mice involving intracerebral inoculation of brain homogenates from G51D PD or MSA cases. The red dot indicates the approximate inoculation site. c Kaplan–Meier survival curves for TgM83+/- mice inoculated with G51D PD-1 (red, n = 6), G51D PD-2 (orange, n = 5), or MSA-1 (black, n = 8) brain homogenate. There was a significant difference in the survival curves as determined by the Log-rank test (P = 0.00030)

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Acta Neuropathologica Communications

ISSN: 2051-5960

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