Fig. 7

Summary of microglial changes identified in the human ALS and mouse rNLS motor cortex and hippocampus. The human ALS motor cortex showed increased microglial expression of both Iba1 and CD68, the latter of which strongly correlated with increased pTDP-43 load. Microglial phenotype clusters that were enriched in the ALS motor cortex were defined by high L-ferritin expression. In the rNLS mouse-driven model of ALS, higher microglial CD68 and L-ferritin expression occurred at early and late disease stages, respectively, after pTDP-43 aggregation